PReS-FINAL-2315: Severe cutaneous vasculitis in two patients with juvenile idiopathic arthritis and biologic therapy

Introduction The management of chronic inflammatory autoimmune diseases has been revolutioned by the use of novel biologic agents achieving excellent results in the treatment of Juvenile Idiopathic Arthritis (JIA). These drugs are generally well tolerated but as they are increasingly used, the incidence of adverse reaction is more common. The most frequent are localised at the injection’s site; others include: pustular folliculitis, psoriasis, hydradenitis, Sweet’s syndrome, lupus-like reactions, and palm plantar pustolosis. Cutaneous vasculitis related to TNF-alpha antagonists, such as hypersensitivity and leucocytoclastic vasculitis, has been described as few case reports. Conversely, there are no reports of cutaneous vasculitis induced from other biologic agents. We report two cases of severe cutaneous vasculitis in adolescents with JIA and uveitis under biologic therapy.